Table of Contents
what are the two methods?
At the time of publication (December 2020) there are two methods of taking Nicotinamide Mononucleotide (NMN), they are:
- Orally, by ingesting/swallowing NMN in either capsule form or by mixing it into a liquid or food
- Sublingual NMN, by placing it under the tongue and allowing the NMN to diffuse into the bloodstream through the soft tissue
scientific proof?
At the date of publication there is no scientific proof that Sublingual NMN, as a method, is more superior to the other with regard to getting NMN into our cells were it transforms into Nicotinamide Adenine Dinucleotide (NAD). So for anyone to say sublingual NMN or oral NMN is the most effective way to take NMN is at best misleading at worse it is a lie.
david sinclair’s tweet & newsletter
David Sinclair has, in a newsletter, finally elaborated on his ‘Sublingual Nope’ Tweet, a Tweet that sent the Sublingual NMN community into a ‘flat spin’!
So, what did David Sinclair really mean?
Some people ‘think’ and some NMN companies say that ‘sublingual’ NMN administration’ is the only way to get NMN into your bloodstream.
In his newsletter David Sinclair writes ‘It’s a good way to get a lot of things into your bloodstream, so they might be right.’ Or they might be wrong. ‘Because when it comes to NAD precursors, there’s far more we don’t know than what we do.’
He continues ‘the best evidence will come when placebo-controlled human trials (lots of them) have been completed, until then, anyone who is taking NMN in any way’, is guessing, we all are.’
david sinclair’s comments on NMN companies
More interestingly he also writes ‘Anyone who is selling you NMN as a product, and telling you how to take it, is also guessing.’
Take Alive by Science (formally Alive by Nature, a Sublingual NMN company), in my humble opinion they saw a niche market (sublingual NMN administration) and have exploited it; obviously for profit – they’re not in business to make a loss.
There are many companies selling Nicotinamide Mononucleotide (NMN) supplements, this is a shrewd way to distance themselves from the herd…but as David Sinclair says ‘they, like all of us, are guessing’. When it comes to Sublingual NMN, WE ARE ALL GUESSING!
sinclair’s mice & method of administration?
Another factor to consider is the ‘you must take sublingual NMN’ mantra; the only trails that have produced scientific results have been on mice, how did David Sinclair get his mice to take their Nicotinamide Mononucleotide (NMN) sublingually? He didn’t, they took it orally in their drinking water.
There are those that say the human liver processes NMN differently to rodents and therefore the bio-availability is reduced, they are also guessing – it may be an educated guess, but it is still a guess, we may know when many human trials are complete.
david sinclair’s newsletter
As David Sinclair writes in the newsletter, he will give you the science and what he does, but he will not give medical advice and he will not endorse products.
So the ‘Sublingual Nope’ quote was not advice, but an answer to a question he was asked
Do you take your NMN sublingually?
He answered ‘Sublingual, Nope.’
Those that have watched his interview with Joe Rogan will know he takes 1 gram of NMN (in a capsule) with his morning coffee.
He stresses in his newsletter that he is not saying
“Should YOU take sublingual NMN? Nope.”
“Is sublingual NMN any good? Nope.”
Just “Do I take sublingual? Nope.”
David Sinclair Closes by Saying:
‘I’m going to do my very best to help you understand the science, and I’m going to be as transparent as possible about my own life, but I’m NOT going to tell you how to live yours’.
For those that are interested I do take mine sublingually, but only out of convenience; capsules are more expensive that powder and it is quicker for me to put the NMN under my tongue thanit is to mix it into say water and drink it.
And to be truthful, I am not sure how much of it is actually absorb under my tongue, because as my mouth almost immediately starts to fill with saliva I have to begin to swallow.
Unfortunately, I had to close comments on the Blog because of spammers, more than fifty a day! If you have any questions, please leave them in the comments section of this video: https://bit.ly/38lHEEc
conclusion
There are two methods of taking Nicotinamide Mononucleotide (NMN), they are orally and sublingually. At the date of publication there is no scientific proof that Sublingual NMN is more superior to Oral NMN with regard to getting NMN into our cells where it transforms into Nicotinamide Adenine Dinucleotide (NAD).
Some people ‘think’ and some NMN companies say that ‘sublingual’ NMN administration’ is the only way to get NMN into your bloodstream. In his newsletter David Sinclair writes ‘It’s a good way to get a lot of things into your bloodstream, so they might be right.’ Or they might be wrong. Because when it comes to NAD precursors, there’s far more we don’t know than what we do.’
More interestingly he also writes ‘Anyone who is selling you NMN as a product, and telling you how to take it (companies such as Alive by Science/Alive by Nature), is also guessing’, so these companies could at best misleading you, or more disturbingly lying to you for profit.