Table of Contents
midlife crisis?
It’s not a midlife crisis and I am not looking for the fountain of youth, we are all getting older and we are all going to die; taking (NMN) may not make me immortal, but research has shown that it may improve my quality of life and extend my health-span.
I was once asked if I could choose how I was going to die, how would I like to go? My answer was ‘to be knocked of my mountain bike at the age of ninety-three.’ I think I would now like to change that to one hundred and one!
As I wrote in a my journey to remain fit and healthy thus far has included, the Low Carb High Fat (LCHF) lifestyle and Intermittent Fasting (IF), one of the claimed side-effects of Intermittent Fasting is a longer life, in mice up to 25%.
the joe rogan podcast
As I continued to research ways to remain fit and healthy, I stumbled across NMN and then NAD+ and Resveratrol, but what was the catalyst that really made me sit up and take note of NMN?
I watched the where Dr. David Sinclair explained the findings of his 2013 paper and the effects of NMN boosting NAD+ with mice and improvements in muscle wastage, insulin resistance and inflammation.
the 2013 nmn study
In the , two year old mice were tested for muscle wastage, insulin resistance and inflammation, in humans these are all used as indicators of the aging process; they were then given NMN in their drinking water for one week.
In all cases, after only one week the two year old mice were reflecting the expected findings of six month old mice in the areas of muscle wastage, insulin resistance and inflammation.
In human terms that would be comparable to a seventy-five year old having the results you would expect to see in a twenty-five year old (33.4%). I would be happy with half that, feeling like a fifty year old at seventy-five or feeling like a thirty year old at ninety would be great.
the 2018 nmn study
In a , again on mice, Dr. David Sinclair’s team at the Harvard Medical School found that the aging of blood vessels had been reversed.
The study showed that mice that were given NMN had restored blood vessel growth and had increased muscle endurance by up to 80%.
nmn a pre-cursor to nad+
NMN is the pre-cursor to NAD+, so what you may say? Well NAD+ is used to , at the simplest level – which is the level I like to work at – it turns our food into an energy source that are bodies can actually use.
Another attribute of NAD+ is that it is also responsible for controlling the genes that power the aging process, as we get older so the aging genes are allowed to continue unchecked; ergo we get older. The lower the levels the faster we age. In the Joe Rogan interview David Sinclair says that research has shown that by the time we are fifty we have HALF the levels of NAD than we did when we were twenty!
By increasing NAD through NMN supplementation we can kick start those genes again and get them to slow down the aging process; maybe even reverse it.
In the Joe Rogan video Dr. Sinclair described how he takes 1 gram of NMN a day, I am assuming he has worked up to that.
I started by taking 125 mg a day and I am now up to 1.5 grams a day; this was in October 2020.
Unfortunately, I had to close comments on the Blog because of spammers, more than fifty a day! If you have any questions, please leave them in the comments section of this video: https://bit.ly/35h4JWB
conclusion
As my research into remaining fit and healthy continued I came across a Joe Rogan podcast where he interviewed David Sinclair. During the podcast Sinclair talked about the results of NMN as an NAD booster in two separate studies with mice.
In one study mice treated with NMN had a decrease in muscle wastage, insulin resistance and inflammation, the results if translated into human years would be comparable to a seventy-five year old having the results you would expect to see in a twenty-five year old.
The second Harvard Medical School study showed that mice that were given NMN had restored blood vessel growth and had increased muscle endurance by up to 80%.
Would you like to feel like a fifty-year old at the age of seventy-five?